Thomas P. Wyche, Yanpeng Hou, Emmanuel Vazquez-Rivera, Doug Braun, and Tim S. Bugni*
Pharmaceutical Sciences Division, University of Wisconsin−Madison, 777 Highland Avenue, Madison, Wisconsin 53705, United States
J. Nat. Prod., Article ASAP
DOI: 10.1021/np300016r
Publication Date (Web): April 6, 2012
Copyright © 2012 The American Chemical Society and American Society of Pharmacognosy
A marine
Nocardia sp. isolated from the ascidian
Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B–F (
1–
5), which show distinct similarities to the previously reported
l-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (
4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey’s method was used to determine the absolute configurations of the amino acids. Peptidolipins B (
1) and E (
4) demonstrated moderate antibacterial activity against methicillin-resistant
Staphylococcus aureus and methicillin-sensitive
Staphylococcus aureus.
