Adonis
Adonis vemalis L.; Family Ranunculaceae
Adonis vemalis L.; Family Ranunculaceae
DESCRIPTION
Medicinal Parts: The medicinal part is derived from the aerial parts of the herb, which are collected during the flowering season and dried.
Flower and Fruit: The erect, solitary, terminal flower is 4 to 7 cm in diameter and the 5 broad-ovate, downy sepals are half as long as the petals. The 10 to 20 petals are narrow, wedge-shaped, simple or finely serrated at the tip. They are 20 to 40 mm long and lemon-yellow, splayed, glossy, reddish on the outside or greenish-tinged. There are numerous stamens and carpels. The small fruit forms a globose capitulum. The fruit is tomentose, wrinkled, laterally veined and keeled widi a sideways-facing, hook-shaped beak. The fruit are arranged on the spindle-shaped, oblong receptacle.
Leaves, Stem and Root: The plant is 10 to 40 cm high with a sturdy, black-brown rhizome. The stem is erect, undivided, covered with scales at the base, vertically grooved and succulent. There are few branches. The leaves have many slits and a curved, glabrous or sparsely haired tip. The middle leaves are half-clasping.
Characteristics: Adonis is a poisonous plant.
Habitat: This Siberian/east European plant is found in the north as far as the central Urals and southwest Sweden. In central Europe, it is limited to the basins of the Weichsel and the Oder as far as the Main and Rhine.
Production: The drug is gathered in forests and should be dried quickly.
Not to be Confused With: Other Adonis species may be added to Adonidis herba.
Other Names: False Hellebore, Yellow Pheasant's Eye, Oxeye, Sweet Vernal, Pheasant's Eye, Red Morocco, Rose-a-Rubie
ACTIONS AND PHARMACOLOGY
COMPOUNDS
Cardioactive steroid gylcosides (cardenolids): including adonitoxin, k-strophanthoside, k-strophanthoside-{3 and cymarin
Flavonoids: including vitexin and luteolin
EFFECTS
Adonis has a positive inotropic effect. Animal tests demonstrated a tonic effect on the veins. The adonitoxin component is slightly more toxic than coumarin.
The drug is insufficiently documented.
INDICATIONS AND USAGE
Approved by Commission E:
• Nervous heart complaints
Unproven Uses : The drug is used for mild impairment of heart functions (NYHA I and II), especially when accompanied by nervous symptoms.
In Russian folk medicine, the drug is used for dehydration, cramps, fever and menstrual disorders, but efficacy is unproven.
Homeopathic Uses: Preparations of Adonis vemalis are used for cardiac insufficiency.
CONTRAINDICATIONS
Adonis is contraindicated in conjunction with digitalis glycoside therapy and also in potassium deficiency.
PRECAUTIONS AND ADVERSE REACTIONS
General: Despite the strong efficacy of the drug's cardioactive steroid gylcosides in parenteral application, serious poisoning in the course of per oral administration is hardly to be expected due to the low resorption rate.
Drug Interactions: Enhancement of efficacy, and thus also of side effects, with simultaneous administration of quinidine, digoxin, calcium, saluretics, laxatives and extended therapy with glucocorticoids.
OVERDOSAGE
For possible symptoms of overdose and treatment of poisonings see Digitalis folium.
DOSAGE
Mode of Administration: Comminuted herb and preparations thereof for internal use.
Daily Dosage: The average daily dose is 0.5 gm of standardized Adonis powder. The maximum single dose is 1.0 gm; maximum daily dose is 3.0 gm.
Homeopathic Dosage: From D2: 5 to 10 drops, 1 tablet or 5 to 10 globules, 1 to 3 times daily; Injection solution: 1 ml once a week sc. From D4: Injection solution: 1 ml twice weekly sc.
Storage: Adonis herb and powder should be stored carefully. Adonis powder should be stored away from light in tightly sealed containers.
LITERATURE
Brevoort P, Der Heilpflanzenmarkt der USA - Ein Uberblick. In: ZPT 18(3): 155-162. 1997. ESCOP-Monographs. In: ESCOP-Monographs Fascicule I and II. 1996.
Hiller KO, Rahlfs V, Therapeutische Aquivalenz eines hochdosierten Phytopharmakons mit Amytriptylin bei angstlichdepressiven Versimmungen - Reanalyse einer randomisierten Studie unter besonderer Beachtung biometrischer und klinischer Aspekte. In: Forsch.
Karrer W, (1950) Helv Chim Acta.33:433.
Lee MK, et al., Antihepatotoxic activity of Icariin, a major constituent of Epimedium koreanum. In: PM 61(6):523-526. 1995.
Loew, Buch. In: Loew D, Rietbrock N: Phytopharmaka II: Forschung und klinische Anwendung, Steinkopff Verlag, Darmstadt, 1996.
Loew DA, Loew AD, Pharmakokinetik von herzglykosidhaltigen Pflanzenextrakten. In: ZPT 15(4): 197-202. 1994.
Loew D, Phytotherapie bei Herzinsuffizienz. In: ZPT 18(2):92-96. 1997.
Martinez-Vazquez M, Ramirez Apan TO, Hidemi Aguilar M, Bye R, Analgesic and antipyretic activities of an aqueous extract and of the flavone Linarin of Buddleia cordata. In: PM 62:137-140. 1996.
Reinhard KH, Uncaria tomentosa (WILLD.) DC. - Cat's claw, Una de gato oder Katzenkralle Protrait einer Arzneipflanze. In: ZPT 18(2): 112-121. 1997.
Sandberg F, Thorsen R, (1962) Lloydia 25(3):201. Schulz V, Hubner WD, Ploch M, Klinische Studien mit Psycho-Phytopharmaka. In: ZPT 18(3): 141-154. 1997.
Winkler C and Wichtel M, (1985) Pharm Acta Helv 60(9/10): 234. Further information in: Frohne D, Pfander HJ, Giftpflanzen - Ein Handbuch fur
Apotheker, Toxikologen und Biologen, 4. Aufl., Wiss. Verlags-Ges Stuttgart 1997.
Hansel R, Keller K, Rimpler H, Schneider G (Hrsg.), Hagers
Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6 (Drogen), Springer Verlag Berlin, Heidelberg, New York, 1992-1994.
Lewin L, Gifte und Vergiftungen, 6. Aufl., Nachdruck, Haug Verlag, Heidelberg 1992.
Madaus G, Lehrbuch der Biologischen Arzneimittel, Bde 1-3,
Nachdruck, Georg Olms Verlag Hildesheim 1979. Roth L, Daunderer M, Kormann K, Giftpflanzen, Pflanzengifte, 4. Aufl., Ecomed Fachverlag Landsberg Lech 1993.
Schulz R, Hansel R, Rationale Phytotherapie, Springer Verlag Heidelberg 1996.
Steinegger E, Hansel R, Pharmakognosie, 5. Aufl., Springer Verlag Heidelberg 1992.
Teuscher E, Biogene Arzneimittel, 5. Aufl., Wiss. Verlagsges. Stuttgart 1997.
Teuscher E, Lindequist U, Biogene Gifte - Biologie, Chemie, Pharmakologie, 2. Aufl., Fischer Verlag Stuttgart 1994.
Wagner H, Wiesenauer M, Phytotherapie. Phytopharmaka und pflanzliche Homoopathika, Fischer-Verlag, Stuttgart, Jena, New York 1995.
